Jeffrey M. Toth, Ph.D.

Adjunct Professor of Biomedical Engineering Director of Biomaterials Research Marquette University Wehr Physics Building Office: Physics Room 113B Phone: (414) 288-6136 Fax: (414) 288-6063 Email: jtoth@mcw.edu

Research Interests:

• Dental and orthopaedic tissue engineering; bone tissue
  engineering
• Bone Grafts and bone graft substitutes; biology, immunology, mechanical characterization

• Fabrication, characterization, and evaluation of ceramic biomaterials for orthopaedic and dental applications, particularly calcium phosphate ceramics as bone graft substitutes

• Characterization and pre-clinical testing of orthopaedic and dental biomaterials - materials, surfaces, and host-response characterization (selection, design, methods, and application of biocompatibility studies)

• Mechanisms and clinical uses for osteoinductive substances and materials

Professional Preparation

Affiliations

Relevant Publications

Easley NE, Wang M, McGrady L, and Toth JM: Biomechanical and Radiographic Evaluation of an Ovine Model for Human Lumbar Spine. Accepted and In Press, Journal of Engineering in Medicine, Proceedings of the Institution of Mechanical Engineers, Part H, 2008.

Thomas KA, Toth JM, Crawford NR, Seim HB, and Turner AS: Bioresorbable Polylactide Interbody Implants In An Ovine Anterior Cervical Discectomy And Fusion Model: 3 Year Results. SPINE 33(7):734-742, April 1, 2008.

Al Jabbari YS, Fournelle RA, Ziebert G, Toth JM, and Iacopino AM: Mechanical Behavior and Failure Analysis of Prosthetic Retaining Screws after Long-Term Use In-vivo. Part IV: Failure Analysis of 10 Fractured Retaining Screws Retrieved from three Different Patients. J Prosth Dent. 201-210, Apr 2008.

Al Jabbari YS, Fournelle RA, Ziebert G, Toth JM, and Iacopino AM: Mechanical Behavior and Failure Analysis of Prosthetic Retaining Screws after Long-Term Use In-vivo. Part III: Preload and Tensile Fracture Load Testing. J Prosth Dent. 192-200, Apr 2008.

Al Jabbari YS, Fournelle RA, Ziebert G, Toth JM, and Iacopino AM: Mechanical Behavior and Failure Analysis of Prosthetic Retaining Screws after Long-Term Use In-vivo. Part II: Metallurgical and microhardness analysis. J Prosth Dent. 17(3):181-191, Apr 2008.

Al Jabbari YS, Fournelle RA, Ziebert G, Toth JM, and Iacopino AM: Mechanical Behavior and Failure Analysis of Prosthetic Retaining Screws after Long-Term Use In-vivo. Part I: Characterization of adhesive wear and structure of retaining screws. J Prosth Dent. 17(3):168-180, Apr 2008.

Roberts HW, Toth JM, Berzins DW, Charlton DG: Mineral Trioxide Aggregate: A Versatile Biomaterial for Endodontic Treatment. Dental Materials, 24:149-164, 2008.

Toth JM: Invited POINT of VIEW “Efficacy of Mesenchymal Stem Cell Enriched Grafts in an Ovine Posterolateral Lumbar Spine Model” SPINE 32(7):727, April, 2007.

Zanella J, Oliver C, Peckham S, McKay WF, Toth JM, Boden SD: Effect on bone induction of using contrast media to reconstitute recombinant human bone morphogenetic protein–2 in an ectopic model in rats. Journal of Neurosurgery: SPINE, 5:434–439, November, 2006.

Anderson PA, Kurtz S, Toth JM: Explant Analysis of Total Disc Replacement. Seminars in Spine Surgery. 18(2): 109-116, June, 2006.

Toth JM, Wang M, Estes BT, Scifert JL, Seim HB 3rd, Turner AS: Polyetheretherketone (PEEK) as a Biomaterial for Spinal Applications. Biomaterials 27(3): 324-334, January 2006.

Copps-Wood K, Berzins DW, Luo Q, Thompson GA, Toth JM, and Nagy WW: Resistance to Fracture of two all-ceramic Crown Materials Following Endodontic Access. The Journal of Prosthetic Dentistry. 95(1):33-41, January, 2006.

Toth JM: Invited POINT of VIEW “Comparison of HEALOSTM/Bone Marrow to INFUSETM(rhBMP-2/ACS) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion” SPINE, 30(9):1007, May 2005.

Gosain AK, Riordan P, Song L. Amarante MT, Kalantarian B, Nagy PG, Wilson CR, Toth JM, and McIntyre BL: A 1-Year Study of Hydroxyapatite-Derived Biomaterials in an Adult Sheep Model: III. Comparison with Autogenous Bone Graft for Facial Augmentation. Plastic and Reconstructive Surgery 116(4):1044-1052, September 15, 2005.

Chow D, Stover S, Bahcall JK, Jaunberzins A, and Toth JM: An in vitro Comparison of the Rake Angles Between K3® and Profile® Endodontic File Systems. Journal of Endodontics, 31(3):180-182, March 2005.

Cooley BC, Daley RA, and Toth JM: Long-Term de novo Bone Formation after Intramuscular Injection of Bone Morphogenetic Protein-2. Journal of Microsurgery, 25(2):167-173, February, 2005.

Gosain AK, Riordan PA, Song L, Amarante MT, Kalantarian B, Nagy PG, Wilson CR, Toth JM, McIntyre BL: A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: Part II. Bioengineering implants to optimize bone replacement in reconstruction of cranial defects. Plastic and Reconstructive Surgery, 114(5): pp 1153-1163, October 2004.

Anderson PA, Rouleau JP, Toth JM, and Riew KA: A Comparison of Simulator Tested and Retrieved Cervical Disc Prostheses. Journal of Neurosurgery: Spine, 1(2):202-210, September 2004.

Klopp LS, Welch WC, Tai J, Toth JM, Cornwall GB, Turner AS: Use of Polylactide Resorbable Film as a Barrier to Postoperative Peridural Adhesion in an Ovine Dorsal Laminectomy Model. Neurosurgical Focus, 16(3):8-16, March 2004.

Toth JM: Chapter 5: “Biocompatibility and Odontocompatibility Assessment of Dental Materials.” In: Contemporary Dental Materials. Ed. by VB Dhuru. Oxford University Press, New Delhi, India, pp 33-41, 2004.

Toth JM, Wang M, Scifert J, Cornwall GB, Estes BT, and Turner AS: Evaluation of PLDLA as a Biomaterial for Use as a Resorbable Interbody Fusion Cage: A study in Sheep. Orthopedics, 25(10): S1131-1140, October 2002.

Welch WC, Cornwall GB, Toth JM, Turner AS, Thomas KA, Gerszten PC, and Nemoto EM: The Use of a Resorbable Film as an Adhesion Barrier. Orthopedics, 25(10): S1121-1130, October 2002.

Sandhu HS, Toth JM, Diwan AD, Seim III, HB Kanim LEA, Kabo JM, and AS Turner: Histological Evaluation of the Efficacy of rhBMP-2 when Compared to Autograft Bone in Sheep Anterior Interbody Fusion. SPINE, 27(6): 567-575, Mar 15, 2002.

Gosain AK, Song L. Riordan P, Amarante MT, Nagy PG, Wilson CR, Toth JM, and Ricci JL: A One Year Study of Osteoinduction in Hydroxyapatite-Derived Biomaterials in an Adult Sheep Model. Plastic and Reconstructive Surgery, 109(2): pp 619-630, Feb. 2002.

Ninomiya JT, Struve JS, Toth JM: Effects of Hydroxyapatite Particulate Debris on the Production of Cytokines and Proteases in Human Fibroblasts. Journal of Orthopaedic Research, 19(4): 621-628, 2001.

Toth JM, Seim III HB, Schwardt JD, Humphrey WB, Wallskog JA, and Turner AS: “Direct Current Electrical Stimulation Increases the Fusion Rate of Spinal Fusion Cages.” SPINE, 25(20):2580-2587, 2000.

Vogelin E, Jones NF, Huang JI, Brekke JH, and Toth JM: Practical Illustrations in Tissue Engineering: Surgical Considerations Relevant to the Implantation of Osteoinductive Devices. Tissue Engineering, 6(4): 449-460, August, 2000.